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Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model: Correlation with Metabolomic Profile ebook

by Shaistha Zaheeruddin


Shaistha Zaheeruddin.

Shaistha Zaheeruddin. References (0). Citations (0).

Effects of curcumin on bop induced oxidative stress in hamster model: Correlation with metabolomic profile. Shaistha Zaheeruddin. The Allen Institute for Artificial IntelligenceProudly built by AI2 with the help of our.

Effect of curcumin on diabetes-induced oxidative stress in the retina

Effect of curcumin on diabetes-induced oxidative stress in the retina. a) Total antioxidant capacity of the retina was quantified by measuring the ability of the retina to inhibit oxidation of ABTS by metmyoglobin using 5–10 μg retina protein. b) Retinal GSH was estimated in the deproteinizing retinal homogenate using a kit from Cayman Chemical (MI). Effect of curcumin on oxidatively modified DNA levels in the retina. Values are represented as mean ± SD of 6–8 rats in each group. P < . 5 compared to normal, and < . 5 compared to diabetes + curcumin.

Effect of curcumin on diabetes-induced oxidative stress in the retina. a) Total antioxidant capacity of the retina was quantified by measuring the ability of the retina to inhibit oxidation of ABTS by metmyoglobin using 5–10 μg retina protein

Effect of curcumin on diabetes-induced oxidative stress in the retina. Each sample was measured in duplicate, and the values are represented as mean ± SD of 7–8 rats in diabetes group and 7–9 rats each on normal and diabetes + curcumin groups.

Local anesthetic toxicity; oxidative stress; metabolomics profiling; apoptotic cell death . To assess the effects of stressor exposure on MMP, cells were

Local anesthetic toxicity; oxidative stress; metabolomics profiling; apoptotic cell death pathways; flow cytometry; mass spectrometry. metabolomics, and genomics involved in cell malfunction and death it was necessary to. establish comparable toxic concentrations; thus, the initial set of experiments was constructing. dose response curves to varying concentrations of hydrogen peroxide and lidocaine. To assess the effects of stressor exposure on MMP, cells were. treated with an LC50 dose of hydrogen peroxide and lidocaine. Samples were taken temporally.

Structure (Molecular Modeling Database). These findings indicate that curcumin supplementation can attenuate exercise-induced oxidative stress by increasing blood antioxidant capacity. The purpose of this study was to investigate the effects of curcumin supplementation on exercise-induced oxidative stress in humans. 10 male participants, ages 2. ±2.

Determination of oxidative stress by PC assessment. Treatment with Curcumin significantly. increased TAC. level in a dose dependent manner on a rat inflammation model. Higher liver TAC values were reported in a post. The determination of carbonylated proteins represents an. easy technique that quantifies the oxidative modifications.

Oxidative stress is certainly a result of excessive fat accumulation . Zingg JM, Hasan ST, Meydani M. Molecular mechanisms of hypolipidemic effects of curcumin.

Oxidative stress is certainly a result of excessive fat accumulation, but it has also been shown that oxidative stress, per se, leads to weight gain; therefore, it is not easy to establish the correct cause-effect relationship between obesity and oxidative stress.

I found that the oxidative stress and metabolic responses induced by Cu in killifish acclimated to SW differed only . This thesis is organized in a sandwich format approved by McMaster University and with the recommendation of the advisory committee. The thesis consists of four chapters.

I found that the oxidative stress and metabolic responses induced by Cu in killifish acclimated to SW differed only slightly from those in FW. I found that Cu had no effect on oxygen consumption rates after 96-h exposure in both FW and SW-acclimated fish, however Cu greatly reduced opercular frequency. In addition, we found that Cu-induced antioxidant protection pathways, although the response differed depending on the specific enzyme.

Oxidative stress (OS) is associated with many chronic states including cancer. Curcumin, a bioactive chemical of turmeric has potent antioxidant effects. We utilized metabolomics to evaluate signatures of OS in BOP (N-nitrosobis-2-(oxopropyl) amine) induced hamsters and their effect by curcumin. 32 hamsters were randomized into treatment (n=20; OS induced by BOP) and control (n=12) groups. After 12 weeks each group was subdivided by no (T0, C0) or 2% curcumin (T2, C2) diet. Proton nuclear magnetic resonance spectroscopy was conducted on urine and analyzed using Principal Component Analysis PCA;SIMCA P+, Umetrics. The PCA score plots showed clear separation between spectra from treatment (T0) and control (C0) groups, and curcumin fed (T2) groups (p<0.05). Partial Least Square (PLS) analysis correlated the metabolomic profiles with Total Antioxidant, cyclooxygenase-2 and NF-kB activity well. Metabolites responsible for the inter-group differences were linked to the pyrimidine, purine and glycine, serine and threonine pathways. With further investigation these metabolites, in addition to providing a mechanistic insight, may serve as potential signatures of OS.
Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model: Correlation with Metabolomic Profile ebook
Author:
Shaistha Zaheeruddin
Category:
Medicine
Subcat:
EPUB size:
1127 kb
FB2 size:
1478 kb
DJVU size:
1325 kb
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Publisher:
LAP LAMBERT Academic Publishing (December 1, 2010)
Pages:
104 pages
Rating:
4.6
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