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Eukaryotic Transcription Factors ebook

by David Latchman,David S. Latchman


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Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states.

Eukaryotic Transcription Factors book.

Familiarity with the mechanisms of eukaryotic gene regulation is now essential for scientists and students in both clinical and basic disciplines. However, the vast array of transcription factors, which are central to such regulation, can prove daunting to students and newcomers to this fascinating field of molecular genetics.

David Seymour Latchman CBE (born 1956) is a British geneticist and university administrator. Since 2003 he has been Master of Birkbeck, University of London, and since 1999 professor of genetics at University College London.

These systems will be described with special attention to the cellular factors required for specific transcription. A section on future prospects will address questions concerning the significance of the complex subunit structure of the nuclear enzymes; the organization and regulation of the gene coding for RNA polymerase subunits; the obtention of mutants affected at the level of factors, or RNA polymerases; the mechanism of template recognition by factors and RNA polymerase. Computational transcription factor binding prediction using random forests.

Academic Press, 21 нояб

Academic Press, 21 нояб. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.

Major families of eukaryotic transcription factors described Mechanisms of gene activation and repression analysed Structure-function relationships . Eukaryotic Transcription Factors - David S. Latchman.

Major families of eukaryotic transcription factors described Mechanisms of gene activation and repression analysed Structure-function relationships indicated Interaction between transcription factors and chromatin structure described Roles in inducible and cell type-specific gene expression Roles in development, differentiation and human diseases including cancer Methods of study in vitro and in vivo.

by David Latchman, David S. Potential of transcription factors as therapeutic targets in human disease. Importance of histone modifications. Use of genome-based sequence analysis and high-throughput methods.

Print Book & E-Book. Eukaryotic Transcription Factors. Affiliations and Expertise. ISBN 9780123739834, 9780080561035. Authors: David Latchman. DNA sequences, transcription factors and chromatin structure Methods for studying transcription factors RNA polymerases and the basal transcriptional complex Families of DNA binding transcription factors Activation of gene expression by transcription factors Repression of gene expression by transcription factors Regulation of transcription factor synthesis Regulation of transcription factor activity Transcription factors and human disease.

Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events.Potential of transcription factors as therapeutic targets in human diseaseImportance of histone modificationsUse of genome-based sequence analysis and high-throughput methodsApplications of the chromatin immunoprecipitation (ChIP) assay Transcriptional elongationRegulation by post-translational modificationsRegulatory networks and bioinformatics
Eukaryotic Transcription Factors ebook
Author:
David Latchman,David S. Latchman
Category:
Medicine & Health Sciences
Subcat:
EPUB size:
1996 kb
FB2 size:
1546 kb
DJVU size:
1784 kb
Language:
Publisher:
Academic Press; 5 edition (December 10, 2007)
Pages:
488 pages
Rating:
4.3
Other formats:
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