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Toxicokinetics and Risk Assessment ebook

by John C. Lipscomb,Edward V. Ohanian


Lipscomb John, Edward V. Ohanian.

Lipscomb John, Edward V.

Lipscomb, John . Ohanian, Edward V. Subject Categories. Medicine, Dentistry, Nursing & Allied Health.

John C. Lipscomb, Edward V. This text clearly demonstrates the application of d pharmacokinetic (PBPK) modeling in human healt.

Toxicokinetics in Risk Assessment discusses the noncancer risk assessment process and its reliance on uncertainty . Toxicokinetics and Risk Assessment book. First Published 2007.

Toxicokinetics and Risk Assessment book.

Personal Name: Ohanian, Edward . Health risk assessment Pharmacokinetics Toxicology Risk Assessment methods.

Personal Name: Ohanian, Edward V. Rubrics: Health risk assessment Pharmacokinetics Toxicology Risk Assessment methods. Download PDF book format. Download DOC book format.

Finding books BookSee BookSee - Download books for free. Toxicokinetics and Risk Assessment. C. Lipscomb John, Edward V.

Toxicokinetics (often abbreviated as 'TK') is the description of both what rate a chemical will enter the body and what occurs to excrete and metabolize the compound once it is in the body. It is an application of pharmacokinetics to determine the relationship between the systemic exposure of a compound and its toxicity. It is used primarily for establishing relationships between exposures in toxicology experiments in animals and the corresponding exposures in humans

Lipscomb JC, Ohanian EV, eds. Thompson C, Johns D, Sonawane B et al. Database for physiologically based pharmacokinetic modeling: physiological data for healthy and health-impaired elderly. J Toxicol Environ Health B 2009; 12:1–24.

Lipscomb JC, Ohanian EV, eds. New York: Informa Healthcare, 2006:361. 46. Balaz S, Lukacova V. A model-based dependence of the human tissue/blood partition coefficients of chemicals on lipophilicity and tissue composition. QSAR 2000; 18:361–368. 47. Béliveau M, Lipscomb J, Tardif R et al. Toxicokinetics and risk assessment, Toxicokinetics and risk assessment, کتابخانه دیجیتالی دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی. Influence of thiazide on salt hypertension. Junichi Iwai, Edward V. Ohanian, Lewis K. Dahl.

Toxicokinetics in Risk Assessment discusses the noncancer risk assessment process and its reliance on uncertainty factors in order to facilitate the continued study and refinement of the scientific basis for health risk assessment. This text clearly demonstrates the application of physiologically-based pharmacokinetic (PBPK) modeling in human health risk assessment, as well as methods for data generation, extrapolation, and inclusion of laboratory results for chemical metabolism and computer-based predictions of biochemical constants to address estimates of variability between experimental animals and humans. This guide also includes recent examples of the use of toxicokinetic information to successfully replace default values for uncertainty factors with data-derived factors in risk assessments developed by the US Environmental Protection Agency.
Toxicokinetics and Risk Assessment ebook
Author:
John C. Lipscomb,Edward V. Ohanian
Category:
Medicine & Health Sciences
Subcat:
EPUB size:
1322 kb
FB2 size:
1987 kb
DJVU size:
1831 kb
Language:
Publisher:
CRC Press; 1 edition (October 10, 2006)
Pages:
361 pages
Rating:
4.7
Other formats:
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